IndraLab

Statements

TRH inhibits KCNH2. 4 / 4
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"This demonstrates that the presence of the proximal domain sequence between residues 325 and 346 is required for the TRH induced slowing of HERG activation."
12560090
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"In cells of two tumours tested, thyrotropin releasing hormone significantly reduced the amplitude of the HERG currents."
12634931
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"TRH reduced the maximal available erg current amplitude by 12% (erg1), 13% (erg2) and 39% (erg3) and accelerated the time course of erg1 and erg2 channel deactivation, whereas erg3 deactivation kinetics were not significantly altered."
11283231
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"Rat erg1 currents recorded in the cell attached configuration were reduced by application of TRH to the extra-patch membrane in the majority of the experiments, confirming the involvement of a diffusible second messenger."
11283231