IndraLab

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USP15 activates Neoplasms. 13 / 13
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"In addition to promoting proliferation, migration, and invasion of ccRCC cells, USP15 accelerated tumor in situ growth and lung metastasis in experimental animals."
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"The deubiquitinating enzyme Ubiquitin-specific peptidase 15 (USP15) is upregulated in various cancers and promotes tumor progression by increasing the expression of several oncogenes."
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"USP15 can stabilize MDM2 and negatively regulate the protein level of p53, and inactivation of USP15 can induce tumor apoptosis and improve the antitumor T-cell response[14]."
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"USP15 knockdown inhibits tumor growth in vivo."
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"Knockdown of USP15 inhibited tumor growth in vivo."
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"In vivo, USP15 depletion indeed inhibited tumor growth, accompanied with elevated p21 , p57 , direct TBX3 repressing targets, thus restricted cell proliferation (Fig. 3c−e, Supplementary Fig. 2g)."
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"Thus, USP15 promotes tumor cell proliferation and tumor growth through maintaining TBX3 level and related downstream events.To understand how the proteostasis regulation fits in the in vivo highly spontaneous BRAF -induced tumorigenesis where Tbx3 is re-activated and critically required for tumor initiation and progression , we first collected tumor tissues from mPTC model generated by crossing thyroid peroxidase TPO-Cre with LSL-Braf (Supplementary Fig. 2h) ."
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"Employing colon orthotopic and metastatic tumor models, we performed loss- and gain-of-function assays for USP15, and revealed that over-expression of USP15 promotes tumor progression by increasing the abundance of myeloid-derived suppressor cells (MDSCs) and decreasing the presence of CD8+T cells in the TME."
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"USP15 accelerated tumor growth and lung metastasis in vivo."
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"HOXA3 or USP15 knockdown suppressed tumor growth and M2-type macrophage infiltration in vivo ."
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"Compared with the scramble shRNA group, USP15 knockdown reduced tumor volume and weight (Figure 6B and C)."
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"Furthermore, knockdown of BMI1 or USP15 inhibited the enhanced tumor growth by IL1R2 overexpression in vivo (Figure 4K; Figure S5D, Supporting Information), and also inhibited the BTICs enrichment in the xenograft tumors (Figure 4L)."
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"Consequently, USP15 deficiency inhibits melanoma tumor cell proliferation and xenografted tumor growth in the TBX3-dependent manner, which is consistent with reported USP15 function in melanoma development (Fig. 5h, Supplementary Fig. 4d, e)."
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