IndraLab

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USP19 increases the amount of calcium(2+). 5 / 5
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"Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer."
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"Fluorescence microscopy and flow cytometry revealed a substantial rise in intracellular Ca concentration in USP19‐plasmid‐transfected cells, indicating that USP19 could enhance Ca levels (Figure 2C)."
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"Fluorescence microscopy and flow cytometry revealed a substantial rise in intracellular Ca concentration in USP19 plasmid and siBAG6 transfected cells, indicating that USP19/BAG6 axis could enhance Ca levels through inhibiting BCL2 expression (Figure 6I,J)."
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"Fluorescence microscopy revealed a substantial rise in intracellular Ca concentration in BCL2 plasmid transfected cells, indicating that BCL2 could enhance Ca levels in Figure S3E.To further clarify the regulatory role of BCL2 ubiquitination by USP19 and BAG6, MDA‐MB‐231 cells were co‐transfected with Myc‐USP19, siUSP19, Flag‐BAG6, siBAG6 and HA‐Ub."
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"Additionally, our research identified a novel mechanism by which USP19 elevates intracellular Ca levels to induce ER stress in TNBC, through regulating the ubiquitination and degradation of BAG6 and BCL2."
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