IndraLab

Statements

TSPYL5 inhibits USP7. 5 / 5
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"These observations suggest that TSPY1 and TSPYL5 can induce USP7 degradation via the 26S proteasome system."
29748603
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"USP7 is inhibited in ALT-positive cells by TSPYL5 (testis specific Y-encoded-like protein 5) which normally resides in APBs."
37046606
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"USP7 is the deubiquitylase for the p53 tumour suppressor and TSPYL5 reduces the activity of USP7 towards p53, resulting in increased p53 ubiquitylation."
21170034
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"It has been shown that in breast cancer with a poor prognosis, TSPYL5 promotes the degradation of the tumor suppressor p53 by directly inhibiting ubiquitin-specific peptidase 7 (USP7)—the p53 deubiquitinase [9]."
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"USP7 is inhibited in ALT-positive cells by TSPYL5 (testis specific Y-encoded-like protein 5) which normally resides in APBs."
37046606