IndraLab

Statements

CDK1/2i decreases the amount of USP37. 2 / 2
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"As shown in Fig. 6 C and Fig. S3 D, overexpression of USP37 resulted in an evident decrease in polyubiquitination of ERK1/2, while CDK1/2 inhibitors reversed this function.Intriguingly, we found that CDK1/2i treatment also markedly decreased USP37 protein levels but led to a significant increase in USP37 polyubiquitination (Fig. 6, A and B; and Fig. S3, A–C and E)."
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"Compared with USP37 wild type, the USP37 SA (S628A) mutant failed to deubiquitinate ERK1/2 and USP37 itself (Fig. 6, H and I; and Fig. S3 I), which may explain why CDK1/2i also decreased USP37 protein levels (Fig. 6, A and B; and Fig. S3, A–C)."
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