IndraLab

Statements

USP29 activates TWIST1. 4 / 4
| 4
reach
"Concerning the well‐established significance of TWIST1 in EMT, CSC self‐renewal, metastasis, and chemo‐resistance, we hypothesized that USP29 might promote these malignant processes through stabilizing TWIST1."
36782089
reach
"Likewise, the overexpression of USP29 WT in MDA‐MB‐231 and BT549 cells dramatically increased the half‐life of TWIST1 compared to the 3A mutant (Figure S6E,F, Supporting Information)."
36782089
reach
"Regarding the fact that both USP29 and CDK1 increase the stability of TWIST1, and CDK1 phosphorylates USP29, We hypothesized that the regulation of TWIST1 by CDK1 might be mediated through the activation of USP29 in TNBC."
36782089
reach
"Taken together, these results suggest that USP29 is a bona fide DUB targeting TWIST1 protein for deubiquitination and stabilization.2.3 USP29 Promotes Tumor Progression of TNBC through Stabilizing TWIST1."
36782089