IndraLab

Statements

Zinc atom inhibits CHUK. 3 / 3
| 3
sparser
"For example, the IκB kinase (IKK) members IKKα and IKKβ are inhibited by zinc, albeit at high concentrations of ∼0.5 µM ( xref )."
31305906
sparser
"Although recombinant IKKα was inhibited by zinc, IKKβ (−/−) MEFs that contain IKKα did not exhibit zinc-mediated inhibition, indicating that the primary effect of zinc occurs directly through inhibition of IKKβ and/or IKKβ-related kinase complex formation."
23403290
sparser
"To understand whether zinc selectively inhibits IKKα and/or IKKβ, we exposed IKKβ (−/−) mouse embryonic fibroblast (MEFs) to IL-1β and evaluated NF-κB-mediated function."
23403290