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Statements

USP9X activates MAP3K5. 8 / 8
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"USP9X supports ASK1-mediated signaling by preventing proteasomal degradation of activated ASK1 ( Nagai et al., 2009 )."
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"Because this USP9X-dependent mechanism might enable cells to modulate the magnitude or duration of ASK1 activation that determine cell fate, USP9X may be a key regulator that fine-tunes the ASK1-deped[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, USP9X positively regulates ASK1 activity and ASK1 dependent cell death through the deubiquitination and stabilization of ASK1 [XREF_BIBR]."
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"Because ROS-activated ASK1 has been known to mediate not only cell death but also various cellular responses including inflammatory responses and cardiac hypertrophy in a stimulus- and cellular contex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Because ROS-activated ASK1 has been known to mediate not only cell death but also various cellular responses including inflammatory responses and cardiac hypertrophy in a stimulus- and cellular contex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, USP9X-dependent activation of ASK1 is unlikely because USP9X preferentially interacted with the activated form of ASK1 ( Figure 1 F)."
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"However, USP9X-dependent activation of ASK1 is unlikely because USP9X preferentially interacted with the activated form of ASK1 ( Figure 1 F)."
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"However, SMN protein levels were not affected by H 2 O 2 -mediated ASK1 activation (data not shown), whereas USP9X associates with oxidative stress-activated ASK1 [14] ."
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