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Statements

USP10 activates Phosphatase. 4 / 4
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eidos
"In contrast to TRIM25 , USP10 restored PTEN phosphatase activity and reduced the production of the secondary messenger PI ( 3,4,5 ) P3 , thereby inhibiting AKT / mTOR pro-growth signaling transduction in NSCLC cells ."
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"In contrast to TRIM25, USP10 restored PTEN phosphatase activity and reduced the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate, thereby inhibiting AKT/mammalian target of rapamycin progrowth signaling transduction in NSCLC cells."
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"Our aforementioned studies have shown that USP10 restores the phosphatase activity of PTEN, thereby inhibiting the AKT/mTOR signaling."
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"By countering TRIM25, USP10 rescues PTEN phosphatase activity and reduces the production of PI(3,4,5)P3 in NSCLC cells, therefore inactivating the AKT/mTOR signaling pathway in NSCLC cells (Fig. 5)."
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