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Potassium(1+) activates KCNQ1. 7 / 7
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"As extracellular potassium is increased, the slow inactivation rate also increases—indicating a stabilization of the inactivated state.Based on these findings, we suggest that extracellular potassium [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"There were two types of K+ channels located at the basolateral membrane of rat colon mucosa : Ca2 +-dependent K+ channels and cAMP activated KCNQ1 and KCNE3 channels (Warth et al., 1999; Schroeder et al., 2000; Flores et al., 2007)."
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"Mutations in genes encoding the major potassium ion channels mediating this event, KCNQ1 and HERG, therefore account for ~ 90% of cases of inherited long QT syndrome."
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"Thank you for submitting your article "Allosteric Mechanism for KCNE1 Modulation of KCNQ1 Potassium Channel Activation" for consideration by eLife ."
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"In this study, we tested the hypothesis that Kv7.1 channels are modulated by extracellular potassium."
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"It is likely that the site responsible for the modulation of Kv7.1 by extracellular potassium is located in the pore-region and that this site is altered in Kv7.1/KCNE1 and Kv7.1/KCNE3 channels but no[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Potentially, the modulation of Kv7.1 channels by extracellular potassium may be part of the mechanism underlying potassium-mediated insulin secretion.In conclusion, we have found that Kv7.1 channels a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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