IndraLab

Statements

CDK4 phosphorylates RB1 on S811. 8 / 13
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"CDK4 phosphorylates S807/S811 on Rb, and this partial phosphorylation is needed for CDK2 phosphorylation ."
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"CDK4–cyclin D1 phosphorylates Thr 5 , Ser 249 , Thr 252 , Thr 356 , Thr 373 , Ser 788 , Ser 795 , Ser 807 , Ser 811 , and Thr 826 of pRB."
18938028
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"The resulting loss of CDK4 function prevented downstream Rb phosphorylation at S780 and S807/811, leading to cell cycle arrest by failure at the S-phase checkpoint."
36484997
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"In the late G1 phase, increased cyclin D1 is associated with increased CDK4 activity, which phosphorylates retinoblastoma protein (pRb) on serine 807/811 residues necessary for cell cycle progression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961557
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"In the late G1 phase, increased cyclin D1 is associated with increased CDK4 activity, which phosphorylates retinoblastoma protein (pRb) on serine 807/811 residues necessary for cell cycle progression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961557
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"Cdk4 phosphorylates pRB at specific serine residues, Ser780, Ser795 and Ser807/811, when cells progress from G 0 /G 1 to G 1 /S phases of the cell cycle."
16750360
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"Retinoblastoma protein (pRb) phosphorylation on Ser807 and Ser811 (p-pRb) by CDK4 and CDK6 and D-type cyclins, represents the first step of cell cycle progression after cell activation."
25675863
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"Phosphorylation of Rb at serine 807/811 is mediated primarily by cyclinD and CDK4 (Knudson and Wang, 1996)."
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