IndraLab

Statements

CDK4 phosphorylates RB1 on S811. 13 / 13
1 1 1 | 7 1 2
rlimsp
"Although phospho-Rb (pSer807/811) was specifically phosphorylated by Cdk4 in the G1 phase [12], OGF treatment did not alter the results of Western blot analysis of phospho-Rb (pSer807/811) levels (Fig. 2B)."
18190706
reach
"CDK4 phosphorylates S807/S811 on Rb, and this partial phosphorylation is needed for CDK2 phosphorylation ."
35188696
sparser
"CDK4–cyclin D1 phosphorylates Thr 5 , Ser 249 , Thr 252 , Thr 356 , Thr 373 , Ser 788 , Ser 795 , Ser 807 , Ser 811 , and Thr 826 of pRB."
18938028
reach
"The resulting loss of CDK4 function prevented downstream Rb phosphorylation at S780 and S807/811, leading to cell cycle arrest by failure at the S-phase checkpoint."
36484997
reach
"In the late G1 phase, increased cyclin D1 is associated with increased CDK4 activity, which phosphorylates retinoblastoma protein (pRb) on serine 807/811 residues necessary for cell cycle progression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961557
reach
"In the late G1 phase, increased cyclin D1 is associated with increased CDK4 activity, which phosphorylates retinoblastoma protein (pRb) on serine 807/811 residues necessary for cell cycle progression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961557
rlimsp
"The site-specific inhibition of the phosphorylation of Rb by delta-tocotrienol was tightly associated with a marked reduction in the expression of cyclin D1 and its regulatory partner cyclin-dependant kinase 4 (CDK4), which is responsible for the phosphorylation of Rb at Ser780, Ser795, Ser 807/811 and Thr826."
19035289
biopax:netpath
No evidence text available
14627988
signor
"Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively."
15809340
reach
"Cdk4 phosphorylates pRB at specific serine residues, Ser780, Ser795 and Ser807/811, when cells progress from G 0 /G 1 to G 1 /S phases of the cell cycle."
16750360
reach
"Retinoblastoma protein (pRb) phosphorylation on Ser807 and Ser811 (p-pRb) by CDK4 and CDK6 and D-type cyclins, represents the first step of cell cycle progression after cell activation."
25675863
biopax:phosphositeplus
No evidence text available
reach
"Phosphorylation of Rb at serine 807/811 is mediated primarily by cyclinD and CDK4 (Knudson and Wang, 1996)."
12591091