IndraLab

Statements


CDK4 phosphorylates RB1 on S811. 7 / 7
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"The resulting loss of CDK4 function prevented downstream Rb phosphorylation at S780 and S807/811, leading to cell cycle arrest by failure at the S-phase checkpoint."

"Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively."

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"Retinoblastoma protein (pRb) phosphorylation on Ser807 and Ser811 (p-pRb) by CDK4 and CDK6 and D-type cyclins, represents the first step of cell cycle progression after cell activation."

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"CDK4 phosphorylates S807/S811 on Rb, and this partial phosphorylation is needed for CDK2 phosphorylation ."

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"Phosphorylation of Rb at serine 807/811 is mediated primarily by cyclinD and CDK4 (Knudson and Wang, 1996)."