
IndraLab
Statements
Hexadecanoic acid inhibits MYD88. 3 / 3
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3
reach
"In support of this, we found that palmitate induced inflammatory gene expression was substantially reduced in MyD88 deficient macrophages compared with that in control cells, while completely abolished in TLR4 -/- and partially impaired in TLR2 -/- macrophages, suggesting the possible role of saturated fatty acids (SFAs) in promoting TLR-MyD88-dependent switching of ATMs from M2- to M1 like inflammatory macrophages (unpublished data)."