IndraLab

Statements

USP14 activates cell adhesion. 3 / 3
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"Despite the significant advantages for the characterization of integrin tension in cells, conventional TGT assays have been conducted mostly on flat surfaces; therefore, how the CG-inducing topographical cues influence integrin tension upon cancer adhesion remains largely unknown.Here, in this brief research report, we developed an engineered TGT-coated anisotropic nanopattern providing topographical cues to elucidate a biophysical role of integrin tension in CG-induced adhesion, polarization, and spreading of human breast cancer and normal cells."
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"mTGT overcomes the obstacle that the TGT required for measuring integrin tensions at a low level may not support cell adhesion."
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"Moreover, overexpression of USP14 in MM cell adhesion model could enhance the ability of cell adhesion by regulating Wnt signaling pathways, thereby promoting the CAM-DR in MM."
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