IndraLab

Statements

USP15 inhibits TP53. 4 / 4
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"In addition, USP15 can negatively regulate the function of p53 through affecting de-ubiquitination and stabilizing MDM2."
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"Conversely, increased TIFAB suppresses p53, promoting leukemia cell function through enhanced activity of the ubiquitin-specific peptidase 15."
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"Conversely, downregulation of HOXA9 by RelB and upregulation of HOXA9 by RelA (Figure 1D) suggest that non-canonical and canonical signaling differentially regulate Hoxa9 expression.TIFAB has recently been shown to increase leukemia progenitor cell functions through regulation of ubiquitin-specific peptidase 15 ubiquitin hydrolase activity to repress p53 (Niederkorn et al., 2020b)."
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"Thus, Scaf1 and Usp15 knockout cells share several alterations such as upregulated TNFα signaling and downregulated TGFβ, hedgehog and p53 signaling but also several distinct pathways."
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