IndraLab

Statements

CENPF binds USP4. 18 / 18
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"Taken together, our data showed that a novel USP4-CENPF axis played an important regulatory role in CRC metastasis and may serve as a potential target for CRC treatment."
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"Mechanically, USP4 interacts with CENPF and decreases CENPF ubiquitination levels, thus stabilizing it."
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"Among the candidates, USP4 could interact with CENPF."
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"These data demonstrated that USP4 interacts with CENPF and facilitates ubiquitination of CENPF, stabilizing it and prolonging its lifespan when overexpressed."
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"Expanding on previous discoveries linking CENPF and USP4 to CRC patient prognosis and their involvement in CRC metastasis regulation, we explored the prognostic relevance of USP4-CENPF association."
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"To confirm the relevance of the USP4-CENPF interaction, we first analyzed protein expression of USP4 and CENPF in our clinical samples from two different Cohort."
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"Second, the role of the CENPF-USP4 axis in CRC metastasis has been identified, but the specific downstream molecular mechanisms remain unclear and require further investigation, In particular, the role of autophagy activation in mediating CRC metastasis through CENPF requires more in-depth exploration."
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"In summary, our groundbreaking research, for the first time, has unveiled CENPF as a novel promoter of CRC metastasis and elucidate the molecular mechanism of the interaction between CENPF and USP4 in inducing migration and invasion of colorectal cancer cells, evidenced from molecular, cellular, animal models, and clinical specimens."
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"After identifying the interaction between USP4 and CENPF, we further examined the effectiveness of USP4 on the CENPF mediated enhanced CRC migration, invasion, and metastasis capacity."
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"Taken together, this study describes a novel USP4-CENPF signaling axis which is crucial for CRC metastasis, potentially serving as a therapeutic target and a promising prognostic biomarker for CRC."
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"To determine whether the interaction between USP4 and CENPF also occurs endogenously in CRC cells, immunoprecipitation was performed using anti-USP4 or anti-CENPF antibodies on lysates from HCT116 cells."
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"Mechanistically, we observed that USP4 interacted with and stabilized CENPF via deubiquitination."
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"The USP4-CENPF axis was correlated with clinical outcomes of CRC patients."
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"Notably, the interaction between CENPF and USP4 is intricately linked to CRC metastasis."
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"Therefore, USP4 could interact with CENPF and markedly stabilized CENPF protein expression levels, which was the most promising candidate based on the overlap of these two screenings."
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"USP4 interacts with CENPF and is identified as a candidate DUB for CENPF."
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"Thus, our findings provide a theoretical foundation and innovative insights for the potential development of a possible treatment strategy targeting the USP4-CENPF for CRC metastasis."
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"These data imply that the USP4–CENPF axis plays a role in CRC development."
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