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"Similarly the polyglutamine disease protein ataxin-3 has been reported to cause transcriptional repression by creating the hypoacetylated state of histones H3 and H4 both by blocking the access and by[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The polyglutamine disease protein ataxin-3 has also been reported to cause transcriptional repression by binding histones H3 and H4 thereby blocking access to acetylation sites on these histones."