IndraLab

Statements



reach
"The results indicated that USP3 knockdown led to more lung metastases than the control group, highlighting the metastatic suppressive capacity of USP3 in CRC.Similarly, a xenograft mouse model was established by subcutaneously injecting cells with USP3 knockdown in GC research."

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"USP3 and SMAD4 were directly targeted by miR-224, and overexpression of the USP3 3 ' UTR could inhibit metastasis caused by the loss of USP3."

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"Contrary to the previously described cancers, USP3 is downregulated in CRC, and USP3 deficiency leads to tumor metastasis and poor prognosis which can be inhibited by overexpression of the USP3 3’UTR."

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"These results indicated that the loss of USP3 facilitated tumour progression, while overexpression of the USP3 3 ' UTR inhibited metastasis in CRC cells."