IndraLab

Statements

CICR activates KCNMA1. 3 / 3
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"The coupling between Ca v channel mediated Ca 2+ influx and BK channel activation is not enhanced by CICR, as depleting intracellular stores with thapsigargin (1 microM) only slightly reduced BK currents elicited by voltage steps to -30 mV (to 92 +/- 11% of control, n = 5, P = 0.063; not shown)."
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"RyR mediated CICR could activate local BK channel, induce fast hyperpolarization and inhibit the action of synapses."
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"These findings, combined with the fact that the I to is Ca 2+ -sensitive, suggest that the I to, similar to SMOCs, is a BK channel current activated by CICR from internal stores."
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