IndraLab

Statements


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"Importantly, Hcy induced activation of NLRP3 inflammasomes and production of IL-1beta and IL-18 were substantially blocked by NLRP3 gene silencing."

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"SXBX pill suppresses homocysteine induced vascular smooth muscle cells dedifferentiation by inhibiting NLRP3 inflammasomes activation via ERK and p38 MAPK pathways."

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"In addition, we found that Hcy activated NLRP3 inflammasomes in VSMCs and SXBX pill could attenuate NLRP3 inflammasomes activation."

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"Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m 6 A-YTHDF2-dependent manner * ."

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"This blockade of NLRP3 inflammasome formation was similar to the loss of Hcy-induced NLRP3 inflammasome formation in glomeruli of Nlrp3 mice (Fig. 6a, c)."