IndraLab

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Lead atom inhibits NLRP3. 2 / 2
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"The administration of a non-specific ROS scavenger, PBN, markedly alleviated mechanical allodynia and inhibited the activation of NLRP3 inflammasome in DRGs and sciatic nerve of the paclitaxel-induced neuropathic pain model.Chemotherapy-induced pain is the most common treatment-limiting complication encountered by cancer patients receiving taxane-, vinca alkaloid-, or platin-based chemotherapy."
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"PBN alleviated the mechanical allodynia and inhibited activation of NLRP3 inflammasome in L4-6 DRGs and sciatic nerve after paclitaxel treatment."
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