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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD inhibits RLR. 2 / 2

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"On the other hand, deubiquitinating enzymes (DUBs), such as DUBA XREF_BIBR, CYLD XREF_BIBR, XREF_BIBR and OTUB1/2 XREF_BIBR have been shown to negatively regulate RLR signaling by specifically removing K63 linked polyubiquitin chains from several signaling molecules."

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"Firstly , CYLD was shown to remove K63-linked ubiquitin chains from RIG-I , TBK1 , and IKKepsilon under basal conditions , thereby inhibiting RLR signaling [ 67,68 ] ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...