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CYLD inhibits RLR. 3 / 3
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"On the other hand, whereas CYLD was previously reported to inhibit TLR and RLR pathways ( Friedman et al., 2008; Yoshida et al., 2005; Zhang et al., 2008 ), recently CYLD has been shown to be vital fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Firstly , CYLD was shown to remove K63-linked ubiquitin chains from RIG-I , TBK1 , and IKKepsilon under basal conditions , thereby inhibiting RLR signaling [ 67,68 ] ."
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"On the other hand, deubiquitinating enzymes (DUBs), such as DUBA XREF_BIBR, CYLD XREF_BIBR, XREF_BIBR and OTUB1/2 XREF_BIBR have been shown to negatively regulate RLR signaling by specifically removing K63 linked polyubiquitin chains from several signaling molecules."
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