IndraLab

Statements

IL10 activates IL10RB. 8 / 9
2 | 6
reach
"IL-10 increased Il10rb only in rat."
29780305
reach
"THP-1 macrophages transfected with either unspecific control siRNA or IL10RB specific siRNA were cultivated in different media after transfection and treated with IL10."
25226503
signor
"The il-10r2 chain is ubiquitously expressed, whereas the il-10 activity is restricted mainly to cells of hematopoietic origin (35, 36). This raised the question of why the second chain of the il-10 receptor complex is widely expressed when its function was required only in limited cellular subsets. One hypothesis is that the il-10r2 chain is shared by receptors for ligands other than il-10"
11035029
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"Increased IL-10 levels in the brain activate IL-10R1 and IL-10R2, triggering the JAK1 pathway and promoting the translocation of STAT3 to the nucleus of microglia."
37548933
reach
"In turn, IL-10 secreted by Th1 and T cells stimulate IL-10R1 and IL-10R2 on Kupffer cells and macrophages, causing their prolonged activation."
22973518
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"By contrast, IL-10–stimulated samples exhibited an almost identical expression pattern in both control and IL-10RB Mφs (Fig. 4 A), indicating that IL-10 by itself did not induce a strong transcriptional response even in WT Mφs. Interestingly, control Mφs stimulated with IL-10 plus LPS clustered closer to unstimulated samples, suggesting a partial inhibition of the LPS response by IL-10."
31819956
reach
"IL-10 signals through a receptor complex consisting of two IL-10R1 and two IL-10R2 subunits, which then triggers STAT3 phosphorylation at tyrosine 705 and serine 727 via the phosphorylation of the cytoplasmic tails of IL-10R1 and IL-10R2 driven by JAK1 and Tyk2, respectively."
32425930
signor
"Functionally active il-10 receptors are composed of two distinct subunits. The il-10 receptor ? Chain is a 110-kda polypeptide that plays the dominant role in mediating high affinity ligand binding and signal transduction. The il-10 receptor ? Subunit (also known as crf2_4) is predicted to be a 40-kda polypeptide that is largely required only for signaling."
10347215