IndraLab

Statements

IL10 activates IL10RB. 6 / 9
2 | 6
reach
"IL-10 increased Il10rb only in rat."
29780305
reach
"THP-1 macrophages transfected with either unspecific control siRNA or IL10RB specific siRNA were cultivated in different media after transfection and treated with IL10."
25226503
reach
"Increased IL-10 levels in the brain activate IL-10R1 and IL-10R2, triggering the JAK1 pathway and promoting the translocation of STAT3 to the nucleus of microglia."
37548933
reach
"In turn, IL-10 secreted by Th1 and T cells stimulate IL-10R1 and IL-10R2 on Kupffer cells and macrophages, causing their prolonged activation."
22973518
reach
"By contrast, IL-10–stimulated samples exhibited an almost identical expression pattern in both control and IL-10RB Mφs (Fig. 4 A), indicating that IL-10 by itself did not induce a strong transcriptional response even in WT Mφs. Interestingly, control Mφs stimulated with IL-10 plus LPS clustered closer to unstimulated samples, suggesting a partial inhibition of the LPS response by IL-10."
31819956
reach
"IL-10 signals through a receptor complex consisting of two IL-10R1 and two IL-10R2 subunits, which then triggers STAT3 phosphorylation at tyrosine 705 and serine 727 via the phosphorylation of the cytoplasmic tails of IL-10R1 and IL-10R2 driven by JAK1 and Tyk2, respectively."
32425930