IndraLab

Statements

reach
"Similar to infected macrophages, HIV-1 protease triggered CASP1 activation and cell death was also blocked by MG132, bortezomib, and Me-Bs (XREF_SUPPLEMENTARY)."
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"However, the proteasome inhibitor MG132 inhibited LeTx induced pyroptosis and caspase-1 autoproteolysis altogether (data not shown), thus hampering investigation of the potential role of the proteasome in degrading inflammasome activated caspase-1."
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"We also demonstrated that the proteasome inhibitor MG-132 inhibited the degradation of caspase-1 and aggravated tissue damage by promoting IL-1β and IL-18 production after WT A. baumannii infection."
33571624
eidos
"Consistent with previous studies 38 , 40 , CQ did not affect caspase-1 activation , whereas MG132 decreased caspase-1 activation in a dose-dependent manner ( Figure S3B-C ) ."
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