IndraLab

"We hypothesized that HPCA brings PKCalpha to PDK1, after which PDK1 activates PKCalpha."

"One of the most studied events controlled by ptdins(3,4,5)p3, comprises the activation of a of agc family protein kinases, including isoforms of protein kinase b (pkb)/akt, p70 ribosomal s6 kinase (s6k), serum and glucocorticoid-induced protein kinase (sgk) and protein kinase c (pkc), which play crucial roles in regulating physiological processes relevant to metabolism, growth, proliferation and survival. Here, we review recent biochemical, genetic and structural studies on the 3-phosphoinositide-dependent protein kinase-1 (pdk1), which phosphorylates and activates the agc kinase members regulated by pi 3-kinase. We also discuss whether inhibitors of pdk1 might have chemotherapeutic potential in the treatment of cancers in which the pdk1-regulated agc kinases are constitutively activated."

"We hypothesized that HPCA brings PKCα to PDK1, after which PDK1 activates PKCα."

"For example , PDK1 activates AKT1 , PKCalpha and other AGC kinases by phosphorylation at key sites ."

"In TP MO, the notable protein regulator was detected to be PDPK1 (domain- Pkinase) that activates PRKCE (domain- Pkinase) and PRKCA."