IndraLab

Statements

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"We further show increased anti-parasite immunity driven by dysregulation of Treg by CYLD deletion."
33309741
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"In E. coli induced pneumonia, CYLD has been shown to negatively regulate the immune response by blocking PAMP (Pathogen Associated Molecular Pattern)-induced NF-kB activation [XREF_BIBR]."
25342597
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"CYLD is an inhibitor of the immune response and NF-κB signaling [100,101,102]."
37892185
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"To determine the mechanisms of how CYLD impairs intrinsic immunity to S. aureus, we established CYLD-deficient THP-1 monocytes by CRISPR/Cas9 ( Figure 3A )."
39958342
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"The inhibition of CYLD and/or A20 could enhance the inflammatory or immune response, but the prolonged consequences are unclear and await assessment in animal models and in early clinical trials."
21151032