IndraLab

"Observations that support the inositol depletion hypothesis include the following: (i) therapeutically relevant Li concentrations could directly inhibit purified IMPase from different sources; xref (ii) Li reduced brain inositol levels xref and elevated inositol monophosphate (IP 1 ), the substrate of IMPase, in rat cortex; xref , xref (iii) Li administration reduced sodium- myo -inositol transporter 1 (SMIT1) messenger RNA (mRNA) levels and lowered inositol uptake in astrocyte cultures; xref , xref , xref , xref (iv) studies demonstrated Li inhibition of IMPase and elevated IP 1 levels in rat cortex slices; xref (v) some cellular and behavioral effects of Li such as increasing growth cone area, xref enhancing autophagy, xref suppression of rearing in rats xref , xref and hypersensitivity to pilocarpine-induced seizures were reversed by inositol; xref , xref (vi) reduced brain inositol levels and increased IP 1 levels have been reported in BPD patients treated chronically or acutely with Li compared with healthy controls; xref , xref (vii) Li treatment of BPD patients reduced phosphatidylinositol bisphosphate (PIP 2 ) levels in their platelet membranes; xref and (viii) Abbott et al. xref found that SMIT1 and potassium channel subunits formed complexes and reciprocally regulated each other in the choroid plexus epithelium affecting neuronal excitability."