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USP22 inhibits Melanoma. 3 / 3
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"Ablation of USP22 expression remarkably attenuates melanoma migration, invasion, and epithelial-mesenchymal transition in vitro and suppresses melanoma metastasis in vivo."
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"We found that USP22 deficiency only enhances the vulnerability of melanoma to ferroptosis inducer RSL3 and has no sensitizing effect on other antimelanoma drugs or cell death inducers (Figures 7A and S7A), suggesting that USP22 has a specific sensitization effect on melanoma ferroptosis."
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"Pharmacological inhibition of USP22 by topotecan exerts a similar effect to USP22 knockout in inhibiting melanoma metastasis both in vivo and in vitro."
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