IndraLab

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"Next, overexpression of USP19 markedly reduced the apoptosis rate of cells compared to that in the L-OHP group (Fig. 4H, I)."
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"Furthermore, the flow cytometric analysis demonstrated that the knockdown of USP19 could promote Hep3B and Huh7 cells apoptosis ( Fig. 5 F)."
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"It has been also reported that USP19 inhibits TNFα -induced apoptosis via the stabilization of c-IAP s, which are ubiquitin ligases that regulate the stability of a variety of apoptotic and non-apoptotic proteins [ xref ]."
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"Among the additional 26 genes, we noted that module 28 included USP19 and LRRFIP2, which can inhibit apoptosis or pyroptosis and were higher in HIV-DNA cells, and TLN1 , which is required for antigen-driven T cell proliferation mediated through immunological synapses and was also higher in HIV-DNA cells."
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