IndraLab

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COPS5 activates CPNE1. 5 / 5
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"Collectively, our findings suggest that JAB1 activates the neuronal differentiation ability of CPNE1 through the binding of C2A domain in CPNE1 with MPN domain in JAB1."
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"Defining the interaction modules on both proteins will be important to further characterize the mechanism of CPNE1 mediated cell differentiation by JAB1."
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"Interestingly, JAB1 activated CPNE1 related neuronal differentiation."
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"It is interesting point to find about detail mechanism of JAB1 up-regulation of CPNE1 function.Generally, the function of the MPN domain has been related to ubiquitin isopeptidase and deubiquitinase i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Nevertheless, it is not clear about the mechanism of JAB1 up-regulation of CPNE1 function."
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