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Cycloheximide inhibits RELA. 3 / 3
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"GR also binds other transcription factors, such as for example the p65 chain of NF-kB, AP-1 and p53 which could be involved in DEX mediated effects including anti-proliferation and activation of apopt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine if Nogo can regulate NF-κB p65 protein stability, we treated HepG2 cells with cycloheximide, a potent inhibitor of cellular protein biosynthesis, and found that NF-κB p65 protein degradation was increased in Nogo-deficient HepG2 cells (Fig. 8C), indicating that Nogo deficiency reduces NF-κB p65 protein stability or enhances its degradation, which can be completed by activating proteasome and/or lysosome."
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"Cycloheximide (CHX)-chase assays revealed that CP treatment accelerated the degradation of p65 in both HEK293T cells and BMDMs (Figure 4l, Supplementary Figure dd)."
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