IndraLab

Statements


USP35 deubiquitinates MAVS. 3 / 3
| 3

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"In contrast, both USP35-WT and USP35-CA had no significant effect on the ubiquitination of RIG-I or TBK1 (Fig. 4B, C), indicating that USP35 specifically deubiquitinates MAVS."

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"Moreover, the knockdown of USP35 promoted the ubiquitination of endogenous MAVS (Fig. 4E)."

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"The ubiquitination experiments showed that USP35-WT, but not catalytically inactive USP35-C450A mutant could deubiquitinate MAVS (Fig. 4A)."