IndraLab

Statements

OTUB1 inhibits CD274. 5 / 5
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"All above results imply that OTUB1 might be a potential target for PD-L1/PD-1 therapy related immune evasion and cancer cell immunosuppression, and the results that silenced OTUB1 mediating downregula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, the instability of PD-L1 produced by OTUB1 depletion stimulates the infiltration of more CD8 T cells and the production of more IFN-γ, both of which aid in the development of antitumor immunity against tumors.90 Another research describes a regulatory mechanism for OTUB1 that occurs upstream of the transcription factor."
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"The regulation of PD-L1 degradation by CSN5 or OTUB1 is mainly found in breast cancer ."
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"OTUB1 deubiquitinated and thus prevented the degradation of PD-L1 ."
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"Moreover, USP9X, USP8, and CSN5 can deubiquitinate PD-L1, and OTUB1 increase PD-L1 levels by preventing new synthetic PD-L1 from entering the ERAD."
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