IndraLab

Statements

Simvastatin inhibits JUN. 3 / 3
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"Longitudinal transcriptional profiling revealed that simvastatin downregulated the inflammatory genes fos, jun, and tumor necrosis factor-alpha and upregulated the cell cycle inhibitor p27Kip1, endothelial nitric oxide synthase, and bone morphogenetic protein receptor type 1a."
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"In one study, simvastatin, atorvastatin, and lovastatin were shown to downregulate nuclear factor-kappa B (NF-kappaB), activator protein-1, and hypoxia-inducible factor-1alpha in endothelial and arterial smooth muscle cells, which play a role in downstream activity of pro-inflammatory cytokines, chemokines, adhesion molecules, and growth factors (Dichtl et al. 2003)."
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"Simvastatin (10 μM) downregulates the transcriptional activity of ATF-2 and c-jun, which then causes a dramatic decrease in the proliferative capacity of glioma cells [123]."
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