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USP46 decreases the amount of YAP1. 5 / 5
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"As expected, western blotting results revealed that overexpression of USP46 significantly decreased YAP1 protein expression, as well as expression of CTGF, the target gene of YAP."
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"In contrast, overexpression of USP46 dramatically suppressed the expression of YAP1 in HCC cells."
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"In this study, we found that USP46 also suppresses expression of YAP1, which further broadens the application of USP46 in cancer research.It is well known that the regulation mechanism of YAP1 is comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results suggest that USP46 indirectly reduces YAP1 expression by disrupting MST1 expression.Several studies have suggested that expression of MST1 is decreased in many human cancers, including H[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, silencing USP46 markedly increased protein levels of both YAP1 and CTGF in HCC cells ( Fig. 4 A and B)."
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