IndraLab

Statements

JOSD1 deubiquitinates KRAS. 2 / 2
| 2
reach
"However, neither JOSD1 wild-type nor its enzymatic mutant failed to decrease KRAS polyubiquitination levels (Fig. 2g)."
40240366
reach
"Moreover, our data have demonstrated that JOSD1 does not interact with or deubiquitinate KRAS and its depletion has minimal effects on KRAS-mutant CRC cell growth; the anti-tumor effects of HY041004 on KRAS-mutant CRC are primarily attributed to JOSD2 inhibition."
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