IndraLab

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YOD1 binds MYH9. 8 / 8
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"Mechanistically, YOD1 binds to MYH9 and maintains its stability by removing the K48 ubiquitin chain from MYH9, thereby mediating the microglia polarization signaling pathway to mediate microglia homeostasis."
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"By co-transfecting MYH9 and mutated YOD1 plasmids in NIH/3T3 cells, it was determined that when amino acids 313 to 317 are deleted, YOD1 failed to bind MYH9, while YOD1 with mutations in other domains can still bind to MYH9 and function (Fig. 7H).3.8 YOD1 regulates the deubiquitination of MYH9."
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"β -Amyloid stimulated the expression of YOD1, causing the binding of YOD1 to MYH9."
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"Further, Co-IP verification found that the interaction between YOD1 and MYH9 was significantly increased in brain tissue ( xref D), microglia cells ( xref E), and NIH/3T3 cells ( xref F)."
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No evidence text available
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"In this study, we showed that YOD1 can bind to MYH9 via its C2H2-type domain."
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"Mechanistically, YOD1 binds to MYH9 and maintains its stability by removing the K48 ubiquitin chain from MYH9, thereby mediating the microglia polarization signaling pathway to mediate microglia homeostasis."
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"Further, Co-IP verification found that the interaction between YOD1 and MYH9 was significantly increased in brain tissue (Fig. 7D), microglia cells (Fig. 7E), and NIH/3T3 cells (Fig. 7F)."
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