IndraLab

Statements

OTUB1 inhibits ubiquitylation. 7 / 8
| 7
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"This and other studies have reported that OTUB1 inhibits ubiquitylation by binding to and inhibiting E2 enzymes xref xref xref xref xref ."
24071738
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"These results imply that OTUB1 inhibits the ubiquitylation of SMAD2/3 rather than directly deubiquitylating them."
24071738
sparser
"For example, OTUB1 regulates T cell anergy via GRAIL [ xref ], and in TGFβ induction, OTUB1 inhibits the ubiquitylation of phospho-SMAD2/3 [ xref ]."
25431208
sparser
"Recently, several studies have described a non-canonical mode of OTUB1 action in which OTUB1 inhibits the ubiquitylation of target proteins by binding to and inhibiting the E2 ubiquitin-conjugating enzyme UBE2N (also known as UBC13) independent of its catalytic activity xref xref xref xref ."
24071738
sparser
"Finally, the DUB OTUB1 inhibits RNF168-mediated ubiquitylation in a non-catalytic fashion by binding to UBC13 and inhibiting the formation of Lys63-linked poly-ubiquitin chains []."
22464734
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"OTUB1 inhibits the ubiquitylation of phospho-SMAD2/3 by binding to and inhibiting the E2 ubiquitin-conjugating enzymes independent of its catalytic activity."
24071738
sparser
"This led us to hypothesize that OTUB1 might inhibit the ubiquitylation of SMAD2/3."
24071738