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USP15 activates SMAD2. 2 / 2
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"Our results indicated that USP15 stimulated TGF-beta and SMAD2 signaling and the cartilage phenotype."

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"Moreover, Eichhorn et al. (2012) found that inhibition of USP15 decreased TGF-beta type I receptor and -phosphorylated Smad2 concentrations in these cells, thus corroborating the notion that USP15 sta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"