IndraLab

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USP10 deubiquitinates AMPK. 4 / 4
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"USP10 also interacts with deubiquitinates and enhances the activity of the master energy-sensor AMP-activated protein kinase-α (AMPKα) ."

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"Consistently, in vitro deubiquitination assay showed that USP10 knockdown increased the ubiquitination of AMPKα and USP10 overexpression decreased the ubiquitination of AMPKα in VSMCs ( Fig. 6 G,H)."

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"Deubiquitination and activation of AMPK by USP10."

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"Conversely, USP10 overexpression decreased AMPKα ubiquitination and increased its phosphorylation at threonine 172 site."