IndraLab

Statements


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sparser
"We found that Ubvs that bind to USP2 or USP21 contain a remarkably similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences."

reach
"In the USP2 and USP21 complex structure, the side chain of Ub Lys48 does not occupy the nearby pocket on USP (see XREF_FIG)."

reach
"We first screened a panel of DUBs and found that both USP2 and USP21 bound to endogenous SKP2, but only USP2 deubiquitylated and stabilized SKP2 protein."