IndraLab

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APC_C inhibits USP22. 5 / 5
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"In addition, as described above, APC/C degrades USP22 through CDC20 during withdrawal from the M phase of cell cycle [ 25 ] (see Fig. 4 )."
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"In contrast, the APC and CDC20 E3 ligase complex negatively regulates USP22 activity by targeting it for degradation, presumably allowing CCNB1 downregulation so that cells can exit mitosis and enter anaphase."
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"USP22 is degraded by the APC/C E3 ubiquitin ligase complex, which also targets CCNB1 for destruction [XREF_BIBR, XREF_BIBR], thereby allowing cells to exit from mitosis, presumably by facilitating CCNB1 degradation."
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"Our study demonstrates that USP22 is also a substrate of the APC/C E3 ligase complex, which degrades USP22 during cell exit from M phase."
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"Therefore, APC and CDC20 E3 ligase complex promotes USP22 protein degradation, presumably allowing CCNB1 degradation for cells to exit M phase."
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