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SCN8A binds STAT3. 3 / 3
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"The results of qPCR analysis revealed that the binding of STAT3 to the Scn8a promoter was enhanced in DRG on day 5 and day 15 following L5-VRT compared to the sham group, which can be reversed by the STAT3 activity inhibitor S3I-201 in the modeled rats (Fig. 5a)."
30736806
sparser
"Furthermore, immunoprecipitation and chromatin immunoprecipitation assays demonstrated that L5-VRT increased the binding of STAT3 to the Scn8a (encoding Nav1.6) promoter and the interaction between STAT3 and p300, which contributed to the enhanced transcription of Scn8a by increasing histone H4 acetylation in Scn8a promoter in DRG."
30736806
sparser
"The results of qPCR analysis revealed that the binding of STAT3 to the Scn8a promoter was enhanced in DRG on day 5 and day 15 following L5-VRT compared to the sham group, which can be reversed by the STAT3 activity inhibitor S3I-201 in the modeled rats (Fig.  xref a)."
30736806