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USP8 activates AKT. 5 / 5
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"Basing on the above, we hypothesized that USP8‐mediated PTK7 promoted NSCLC progression by regulating the PIK3CB‐mediated PI3K/AKT pathway."
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"In addition, USP8 regulates the ubiquitination level of ASCL1 and mediates CD47 transcriptional regulation of the AKT pathway to increase the glycolysis level of hBMSCs and cell osteogenic differentiation."
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"USP8 activity thus modulates VEGF-A-stimulated Akt and ERK1/2 activation but does not affect other VEGFR2 associated signal transduction pathways."
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"The results showed that USP8 knockdown inhibited the ratio of p-AKT/AKT in A549 and H1299 cells (Figure 4B)."
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"Thus, the knockdown of USP8 significantly reduced the downstream targets of RTKs including STAT3, Akt, and ERKs both as a phosphorylated and unphosphorylated form in gefitinib-resistant and -sensitive[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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