IndraLab

Statements

USP8 activates AKT. 3 / 3
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"Importantly, knockdown of USP8 inhibited activation of the Akt signaling pathway by decreasing the phosphorylation level of Akt and up-regulated p53 expression, while USP8 overexpression increased activation of the Akt signaling pathway in Hucct-1 cells."
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"USP8 activity thus modulates VEGF-A-stimulated Akt and ERK1/2 activation but does not affect other VEGFR2 associated signal transduction pathways."
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"The results showed that USP8 knockdown inhibited the ratio of p-AKT/AKT in A549 and H1299 cells (Figure 4B)."
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