IndraLab

Statements

reach
"In conclusion, USP22 is upregulated in a variety of malignancies, and studies have shown that USP22 induces tumor resistance to 5-FU by acting on CSCs, SIRT1, and C-MYC."
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"Studies have demonstrated that USP22 directly interacts with SIRT1, activating the AKT/GSK-3β/multidrug resistance-associated protein 1 (MRP1) pathway, thereby enhancing 5-Fu efflux and reducing 5-Fu-induced apoptosis in HCC cells [124]."
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"USP22 up-regulates the SIRT1/AKT/MRP1 signaling pathway and promotes the efflux of 5-Fluorouracil (5-FU), leading to the treatment resistance of HCC [17]."
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