IndraLab

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PSMD14 activates autophagy. 2 / 2
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"When localized to the aggregates, the deubiquitinase activity of RPN-11 and Poh1 releases ubiquitin chains from the aggregated protein, and these ubiquitin chains then serve to activate autophagy via the HDAC6 protein [XREF_BIBR, XREF_BIBR]."
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"We propose that proteasomal Poh1 serves to stimulate compensatory autophagy activity via HDAC6 when the proteasome activity is no longer adequate and challenged by protein aggregates."
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