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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PSMD14 activates autophagy. 2 / 2

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"We propose that proteasomal Poh1 serves to stimulate compensatory autophagy activity via HDAC6 when the proteasome activity is no longer adequate and challenged by protein aggregates."

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"When localized to the aggregates, the deubiquitinase activity of RPN-11 and Poh1 releases ubiquitin chains from the aggregated protein, and these ubiquitin chains then serve to activate autophagy via the HDAC6 protein [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...