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Statements

RIPK1 deubiquitinates CYLD. 2 / 2
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"Therefore, suppressing c-IAP1, the E3 ubiquitin ligase of RIP1, by SMAC mimetics or activating the RIP1 deubiquitylating enzyme CYLD together with suppressing caspase-8 with z-VAD triggers necroptosis in TNFalpha exposed cells XREF_BIBR, XREF_BIBR."
23831571
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"However, the substrates cleaved by the caspase-8/cFLIP L heterodimer to prevent necroptosis have not been thorougly defined.Several proteins involved in necroptosis signaling are known caspase-8 subst[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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