IndraLab

Statements

Topiramate inhibits STAT1. 4 / 4
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"TPM reduces NADPH oxidase components and stat1 activation."
30337926
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"Taken together, our study reveals novel mechanisms for TPM mediated neutrophil reprogramming with reduced bacterial killing activity, in that TPM reduces STAT1 mediated expression of key anti-bacterial molecules such as gp90 and iNOS."
30337926
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"Third, TPM treated neutrophils have reduced activation of STAT1, a key transcription factor involved in the expression of iNOS and key NADPH oxidase components such as gp91."
30337926
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"Mechanistically, we documented that TPM primed neutrophils have reduced STAT1 activation following subsequent LPS challenge."
30337926