IndraLab

Statements

BAP1 binds ARNT. 4 / 4
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"Therefore, we checked whether BAP1 could also bind to HIF-1β."
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"CoIP experiments in cells co-transfected with full length Myc-tagged BAP1 (Myc- BAP1 ) and Flag-tagged full-length HIF-1β, or HIF-1β fragments covering residues 2 to 470 [HIF-1β(2-470)], 142-470 [HIF-1β(142-470)], 471-789 [HIF-1β(471-789)], 582-789 [HIF-1β(592-789)] ( xref ), showed that BAP1 binds to the N terminus region of HIF-1β, specifically to the DNA binding and dimerization region [HIF-1β(2-470) and HIF-1β (142-470)] ( xref )."
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"We found that BAP1 also binds to the N terminus region of HIF-1β, specifically to the DNA binding and dimerization region ( xref )."
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"Aligning the crystal structure of HIF-1α-HIF-1β complex (PDB ID: 4zpr) ( xref ) to our structural model for the binding complex of BAP1 -HIF-1α reveals the significance of residue 1 to 73 of HIF-1α, as this region binds to both BAP1 and HIF-1β ( xref )."
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