IndraLab

Statements

TBX18 increases the amount of HCN4. 2 / 2
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"In this study, the underlying mechanism responsible for this differentiation may involve upregulation of the HCN4 promoter by TBX18, which indirectly increases the expression of HCN4 and enhances the efficiency of the differentiation of ADSCs into pacemaker like cells."
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"Furthermore, Tbx18 gene transfer in mature ventricular cardiomyocytes increases HCN4 channel expression and yields pacemaker activity [XREF_BIBR]."
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