IndraLab

Statements

TBX18 increases the amount of HCN4. 6 / 6
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"Previous studies demonstrated that Tbx18 and Shox2 increased HCN4 expression and induced ESCs, ADSCs and BMSCs to differentiate into pacemaker-like cells (17,32,33)."
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"In this study, the underlying mechanism responsible for this differentiation may involve upregulation of the HCN4 promoter by TBX18, which indirectly increases the expression of HCN4 and enhances the efficiency of the differentiation of ADSCs into pacemaker like cells."
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"Moreover, it has been reported that Tbx18 transfection of neonatal rat myocardium not only increased the expression levels of HCN4, but also increased the frequency of spontaneous beating (5)."
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"Furthermore, Tbx18 gene transfer in mature ventricular cardiomyocytes increases HCN4 channel expression and yields pacemaker activity [XREF_BIBR]."
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"Together, mRNA TBX18 gene transfer in cardiomyocytes led to increased automaticity and Hcn4 expression and slower conduction with lower Cx43 expression, recapitulating key electrophysiological properties of native SAN pacemaker cells ."
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"As shown in figure 5, sustained β-adrenergic receptor blockade resulted in the loss of the day–night rhythm in transcripts for (i) the sinus node-specific Shox2 [35], (ii) Tbx3 and Tbx18, which regulate the pacemaking phenotype and can promote ectopic Hcn4 expression [36,37], and (iii) Mef2c, which is a direct regulator of Hcn4 [38]."
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