IndraLab

Statements

Barium(2+) activates KCNQ1. 4 / 4
| 4
reach
"On the other hand, inhibition of inactivation gating by Ba 2+ in low external K + can not be accounted for by a general slowing of the sequential gating XREF_FIG, since very long depolarizing pulses (+30 mV for 6 min) performed in the presence of 4 mM Ba 2+ did not restore KCNQ1 inactivation, as measured by the hooked tail currents (unpublished data)."
15226366
reach
"Third, high external K + prevented the slowing of KCNQ1 activation kinetics produced by Ba 2+ (XREF_FIG A)."
15226366
reach
"Second, high external K + (50 mM) prevented the slowing of KCNQ1 activation produced by 10 mM Ba 2+, though Ba 2+ washout kinetics were even slower in 50 mM [K +] 0 than in 2 mM [K +] 0 (XREF_FIG A, XREF_TABLE and see below)."
15226366
reach
"The voltage dependent block of KCNQ1 current produced by external Ba 2+ was significantly attenuated in 50 mM [K +] 0, as measured in steady-state experiments."
15226366